BS: Brigham Young University, Provo, Utah
PhD: Washington University in St. Louis, St. Louis, Missouri
Post-Doctoral: Dartmouth Medical School, Hanover, New Hampshire
My laboratory studies the interactions between bacterial pathogens and the host epithelium. Specifically, we are interested in understanding how Pseudomonas aeruginosa exploits underlying lung dysfunction in individuals with cystic fibrosis (CF) to establish and maintain chronic lung infection. After CF lung colonization, P. aeruginosa undergoes genetic regulatory changes leading to the formation of antibiotic-resistant biofilms, which persist in the lung for the life of the patient despite aggressive antimicrobial therapy. We have developed a novel system for the development of P. aeruginosa biofilms on human CF-derived airway epithelial cells in vitro. Using this model, we are identifying factors that impact biofilm antibiotic resistance as well as bacterial virulence in the context of CF lung infection. The overall goal of this research is to better understand the nature of chronic infections so that new and better therapies can be developed.
Moreau-Marquis, S., Redelman, C. V., Stanton, B. A., and Anderson, G. G. 2010. Co-culture Models of Pseudomonas aeruginosa Biofilms Grown on Live Human Airway Cells. Journal of Visualized Experiments 44. http://www.jove.com/video/2186/co-culture-models-pseudomonas-aeruginosa-biofilms-grown-on-live-human, doi: 10.3791/2186.
Anderson, G. G., Yahr, T. L., Lovewell, R. R., and O’Toole, G. A. 2010. The Pseudomonas aeruginosa Magnesium Transporter MgtE Inhibits Transcription of the Type III Secretion System. Infection and Immunity 78(3):1239-1249.
Anderson, G. G., Goller, C. C., Justice, S., Hultgren, S. J., and Seed, P. C. 2010. Polysaccharide Capsule and Sialic Acid-Mediated Regulation Promote Biofilm-like Intracellular Bacterial Communities During Cystitis. Infection and Immunity 78(3):963-975.
Moreau-Marquis, S., Bomberger, J.M., Anderson, G. G., Swiatecka-Urban, A., Ye, S., O’Toole, G. A., and Stanton, B. A. 2008. The DF508-CFTR Mutation Results in Increased Biofilm Formation by Pseudomonas aeruginosa by Increasing Iron Availability. American Journal of Physiology-Lung Cellular and Molecular Physiology 295(1):L25-37. (Selected as “Editorial Focus”)
Anderson, G. G., Moreau-Marquis, S., Stanton, B. A., and O’Toole, G. A. 2008. In vitro Analysis of Tobramycin-Treated Pseudomonas aeruginosa Biofilms on Cystic Fibrosis-Derived Airway Epithelial Cells. Infection and Immunity 76(4):1423-1433. (Selected as a “Spotlight Article” by the Editors)
Anderson, G. G., and O’Toole, G. A. 2008. Innate and Induced Resistance Mechanisms of Bacterial Biofilms, p. 85-105. In Romeo, T. (Ed.), Bacterial Biofilms. Current Topics in Microbiology and Immunology, vol. 322. Springer-Verlag, Berlin.
Anderson, G. G., Lee, Y. M., Smith, C., and Hultgren, S. J. 2006. Mechanisms of Bacterial Adhesion and Consequences of Attachment, p. 207-246. In Nickerson, C. and Schurr, M. (Eds.), Molecular Paradigms of Infectious Disease: A Bacterial Perspective. Springer-Verlag, New York.
Justice, S. S., Hung, C., Theriot, J. A., Fletcher, D. A., Anderson, G. G., Footer, M. J., and Hultgren, S. J. 2004. Differentiation and Developmental Pathways of Uropathogenic Escherichia coli in Urinary Tract Pathogenesis. Proceedings of the National Academy of Sciences 101:1333-1338.
Anderson, G. G., Dodson, K. W., Hooton, T. M., and Hultgren, S. J. 2004. Intracellular Bacterial Communities of Uropathogenic Escherichia coli in Urinary Tract Pathogenesis. Trends in Microbiology 12:424-430.
Anderson, G. G., Martin, S. M., and Hultgren, S. J. 2004. Host Subversion by Formation of Intracellular Bacterial Communities in the Urinary Tract. Microbes and Infection 6:1094-1101.
Anderson, G. G., Palermo, J. J., Roth, R., Heuser, J., Hultgren, S. J. 2003. Intracellular Bacterial Biofilm-like Pods in Urinary Tract Infections. Science 301:105-107.